脑部放疗，上午比下午敏感许多！
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8 u; O3 f; t! Y/ E/ r4 u& d8 ZCancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9./ X3 v. l- q/ V
Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?) l% v V. y: Y9 [# @1 [$ j3 k- {
Rahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
% D! x! P( d( p/ eSourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.) X8 O( ^+ z5 G+ g3 W4 b+ }/ l5 k
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Abstract% q7 l8 e/ h9 N0 O
BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.5 B3 Y: D6 N. U- Y9 K* j7 p
f9 u/ q; J0 \- X$ D" iMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.
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$ m8 z) p0 m$ Q( ` xRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).# q& d; k: ^/ P
4 T- G, Y2 m9 y |( {. A2 k& b3 yCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.
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母亲肺腺癌，9年靶向耐药后，如何选
2017年5月，因持续干咳入院检查，肺部弥漫型结节，支气管镜确诊肺腺癌，四期。基因检
林根教授：肺癌脑膜转移诊断及用药策
整理者：雨过天晴审核人：鹰版癌细胞向中枢神经系统的转移，尤其是脑膜转移，是影响晚
75%手术切除率，29%肿瘤完全清除！联
作者：雨过天晴对于III期非小细胞肺癌（NSCLC）患者而言，手术切除往往面临巨大挑战—
母亲晚期肺癌跨越11年了！我们的5点
讲述者：小白兔整理者：pear
2014年母亲确诊晚期肺腺癌，一路摸索抗癌前行，幸得病友
根治性放疗结束后，免疫维持两年能不
家父2022年12月份确诊右肺上叶肺鳞癌3A期，纵膈淋巴结转移，一直在复肿治疗，先新辅助
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显身卡
