发给老马备查:* P/ G" _3 k1 D, g/ l
滴水察海(69304838) 15:23:23
: j% H- Y9 `, r老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
! r. K. i9 X" s. Q吉非替尼和S-1连用的依据
4 q, ^" p( h* B8 I/ MGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.: B" Y0 |5 P/ J1 m, ]# ~# x7 Y( t
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
% P+ O7 k1 g# N# N: ^8 y9 G* ?这样是不是推理出,耐药后,可以用S-1和培美了?9 e d" t0 }: E, x! y) j) k
结论:3 {) R4 ?4 y! x4 \- k
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |