看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。% ^9 }! { B$ u3 [
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+ e. f# `+ ~) gCurrently available feasibility data for possible combination strategies. * c4 ]; n% b; K- _, ~. I1 d
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Combination Feasibility according to preliminary data ; u. \/ P( j* C6 Q% d$ c
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* `0 q b3 [2 W* RBevacizumab + sorafenib Yes, reduced dose
6 C( ^: ]+ O8 ^# M' s( L+ TBevacizumab + sunitinib† No
" m0 `. o+ H, m8 S6 I9 Z* NBevacizumab + temsirolimus Yes
3 ^2 H) y9 r& B; @' K" aBevacizumab + everolimus Yes 3 Y) i4 j8 C2 _% H' y7 H# y- a8 M1 o
Sorafenib + sunitinib ?
/ ?0 C+ j3 }' l, D' bSorafenib + temsirolimus Yes, reduced dose 9 a# n, `$ m7 E( z+ D
Sorafenib + everolimus Yes, reduced dose # P1 _( r% t R, {
Sunitinib + temsirolimus† No * A: V* ?) D; S2 O
Sunitinib + everolimus ? 8 l& ]* o v) A% c6 `) V/ ?& ]
Temsirolimus + everolimus ?
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4 n! p4 n2 H; }* f. ?†Led to US FDA warning.# ^7 W% e/ {, r* W2 w! p
?: As yet unattempted combination.. P/ o' s; I. r- C1 O# r
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